Dr. Tomás Falzone


PhD in Molecular Biology and genetics from the School of Sciences, University of Buenos Aires (2002). Postdoctoral training at the Cellular and Molecular Medicine Department from the University of California San Diego, USA (2002-2007).

Research Assistant at the Cellular and Molecular Medicine Department from the University of California San Diego, USA (2007-2009).

 In 2009 Tomas returned to Argentina as Researcher at the National Scientific and Technical Research Council (CONICET) in the Institute for cell Biology and Neuroscience (IBCN) and Assistant professor of the School of Medicine, UBA. 

Throughout his career, he has been honoured with the PEW Latin American Fellow Award (2002-2004), Alzheimer Association New Investigator Award (2010-2012), PROLAB IBRO-Program (2016), International Global Ambassador Award (2019), and the International Research Partner Collaboration Program (2022), among other awards and distinctions.

In 2021 he joined the IBIOBA-MPSP as a group leader of the Axonal Transport and Neurodegenerative diseases laboratory.

Selected publications

  • Krzystek, Banerjee, Thurston, Huang, Swinter, Rahman, Falzone T, and Gunawardena S. “Differential mitochondrial roles for α-synuclein in DRP1-dependent fission and PINK1/Parkin-mediated oxidation” Cell Death & Disease, Accepted, 2021.
  • Saez T, Fernandez Bessone I, Rodriguez MS, Alloatti M, Otero MG, Cromberg L, Pozo Devoto V, Oubina G, Sosa L, Buffone MG, Gelman & Falzone T. “Kinesin-1-mediated axonal transport of CB1 receptors is required for cannabinoid-dependent axonal growth and guidance”. Development, Apr 20;147(8), 2020.
  • Cromberg L, Saez T, Otero M, Tomasella E, Alloatti M, Damianich A, Pozo Devoto V, Ferrario J, Gelman D, Rubinstein M & Falzone T. “Neuronal KIF5b deletion induces striatum-dependent locomotor 3 impairments and defects in membrane presentation of dopamine 4 D2 receptors”. Journal of Neurochemistry, Jan 21, 2019.
  • Otero M, Bessone I, Hallberg A, Cromberg L, De Rossi M, Saez T, Levi V, Almenar-Queralt A & Falzone T. “Proteasome stress leads to APP axonal transport defects by promoting its amyloidogenic processing in lysosomes”. Journal of Cell Science, Jun 11;131(11), 2018.
  • Alloatti M, Bruno L & Falzone T. “Methods for Quantitative Analysis of Axonal Cargo Transport”. Methods in Molecular Biology, 1727:217-226, 2018.
  • Pozo Devoto V & Falzone T. “Mitochondrial dynamics in Parkinson’s Disease, a role for α-Synuclein?”. Disease Models and Mechanisms, Review, Sep 1;10(9):1075-1087, 2017.
  • Pozo Devoto V, Dimopoulous N, Alloatti M, Cromberg L, Otero M, Saez T, Pardi, B, Marin-Burgin, Schinder A, Scassa M, Sevlever G & Falzone T. “αSynuclein control of mitochondrial homeostasis in human-derived neurons is disrupted by mutations associated with Parkinson’s Disease”. Scientific Reports, Jul 11;7(1):5042, 2017.
  • Lacovich V, Espindola S, Alloatti M, Pozo Devoto M, Cromberg L, Čarná M, Forte G, Gallo J, Bruno L, Stokin G, Avale M & Falzone T. “Tau isoforms imbalance impairs the axonal transport of the amyloid precursor protein (APP) in human neurons”, Journal of Neuroscience. Jan 4;37(1):58-69, 2017.
  • Otero G, Alloatti M, Cromberg L, Almenar-Queralt A, Encalada S, Pozo Devoto V, Goldstein L, Falzone T. “Fast axonal transport of the proteasome complex depends on membrane interaction and molecular motor function”. Journal of Cell Science, April 1;127, 1537-49, 2014.
  • Almenar-Queralt A, Falzone T, Shen Z, Arreola A, Niederst E, Kim S, Briggs S, Williams S, Goldstein L. “UV Accelerates Amyloid Precursor Protein (APP) Processing and Disrupts APP Axonal Transport”. Journal of Neuroscience, Feb 26;34(9):3320-39, 2014.
  • Falzone T, Gunawardena S, McCleary D, Reis G, Goldstein L. “Kinesin-1 transport reductions enhance human tau hyperphosphorylation, aggregation and neurodegeneration in animal models of tauopathies.. Human Molecular Genetics, Nov 15;19(22):4399-408, 2010.
  • Falzone T, Stokin G, Lillo C, Rodrigues E, Westerman E, Williams D, Goldstein L. “Axonal Stress Kinase Activation and Tau Misbehavior Induced by Kinesin-1 Transport Defects. Journal of Neuroscience. 29(18):5758-67. May 6, 2009.
  • Stokin G, Lillo C, Falzone T, Brusch R, Rockenstein E, Mount S, Raman R, Davies P, Masliah E, Williams D, Goldstein L. “Axonopathy and transport deficits early in the pathogenesis of Alzheimer’s disease”. Science, 307(5713):1282-8, Feb 25, 2005.