SPEAKER: Dr. Daniel Altschuler (Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh)
TITLE: “A new 3-wave model of cAMP signaling”
DATE: Monday, April 29, 12 PM.
VENUE: IBioBA´s seminar room. Godoy Cruz 2390, C1425FQD, Buenos Aires, Argentina.
Abstract
GPCR proteins represent the most extensive class of membrane-bound receptors in mammals, playing crucial roles in cellular communication and response mechanisms. Traditionally, GPCRs are known to activate downstream effectors through G-proteins, with the Gs protein specifically stimulating adenylyl cyclase isoforms to produce the second messenger cAMP. This, in turn, initiates a range of responses both in the cytosol and the nucleus. We will discuss new findings that lay the groundwork for a new ‘3-wave model’ that explains how the cAMP signal is transduced from the membrane to the nucleus.