Dr. Tomás Falzone


Doctorado en Biología Molecular y Genética en la Facultad de Ciencias Exactas de la Universidad de Buenos Aires (2002). Postdoctorado en el Departamento de Medicina Molecular de la Universidad de California San Diego, USA (2002-2007). 

Investigador Asistente en el Departamento de Medicina Molecular de la Universidad de California San Diego, USA (2007-2009).

En 2009 retornó a la Argentina como investigador del CONICET y docente en la UBA, en el Instituto de Biología Celular y Neurociencias (IBCN) de la Facultad de Medicina de la UBA. 

A partir del 2021 está a cargo del grupo de investigación de Transporte axonal y enfermedades neurodegenerativas del IBioBA, y es investigador independiente de CONICET.

Publicaciones destacadas

  • Krzystek, Banerjee, Thurston, Huang, Swinter, Rahman, Falzone T, and Gunawardena S. “Differential mitochondrial roles for α-synuclein in DRP1-dependent fission and PINK1/Parkin-mediated oxidation” Cell Death & Disease, Accepted, 2021.
  • Saez T, Fernandez Bessone I, Rodriguez MS, Alloatti M, Otero MG, Cromberg L, Pozo Devoto V, Oubina G, Sosa L, Buffone MG, Gelman & Falzone T. “Kinesin-1-mediated axonal transport of CB1 receptors is required for cannabinoid-dependent axonal growth and guidance”. Development, Apr 20;147(8), 2020.
  • Cromberg L, Saez T, Otero M, Tomasella E, Alloatti M, Damianich A, Pozo Devoto V, Ferrario J, Gelman D, Rubinstein M & Falzone T. “Neuronal KIF5b deletion induces striatum-dependent locomotor 3 impairments and defects in membrane presentation of dopamine 4 D2 receptors”. Journal of Neurochemistry, Jan 21, 2019.
  • Otero M, Bessone I, Hallberg A, Cromberg L, De Rossi M, Saez T, Levi V, Almenar-Queralt A & Falzone T. “Proteasome stress leads to APP axonal transport defects by promoting its amyloidogenic processing in lysosomes”. Journal of Cell Science, Jun 11;131(11), 2018.
  • Alloatti M, Bruno L & Falzone T. “Methods for Quantitative Analysis of Axonal Cargo Transport”. Methods in Molecular Biology, 1727:217-226, 2018.
  • Pozo Devoto V & Falzone T. “Mitochondrial dynamics in Parkinson’s Disease, a role for α-Synuclein?”. Disease Models and Mechanisms, Review, Sep 1;10(9):1075-1087, 2017.
  • Pozo Devoto V, Dimopoulous N, Alloatti M, Cromberg L, Otero M, Saez T, Pardi, B, Marin-Burgin, Schinder A, Scassa M, Sevlever G & Falzone T. “αSynuclein control of mitochondrial homeostasis in human-derived neurons is disrupted by mutations associated with Parkinson’s Disease”. Scientific Reports, Jul 11;7(1):5042, 2017.
  • Lacovich V, Espindola S, Alloatti M, Pozo Devoto M, Cromberg L, Čarná M, Forte G, Gallo J, Bruno L, Stokin G, Avale M & Falzone T. “Tau isoforms imbalance impairs the axonal transport of the amyloid precursor protein (APP) in human neurons”, Journal of Neuroscience. Jan 4;37(1):58-69, 2017.
  • Otero G, Alloatti M, Cromberg L, Almenar-Queralt A, Encalada S, Pozo Devoto V, Goldstein L, Falzone T. “Fast axonal transport of the proteasome complex depends on membrane interaction and molecular motor function”. Journal of Cell Science, April 1;127, 1537-49, 2014.
  • Almenar-Queralt A, Falzone T, Shen Z, Arreola A, Niederst E, Kim S, Briggs S, Williams S, Goldstein L. “UV Accelerates Amyloid Precursor Protein (APP) Processing and Disrupts APP Axonal Transport”. Journal of Neuroscience, Feb 26;34(9):3320-39, 2014.
  • Falzone T, Gunawardena S, McCleary D, Reis G, Goldstein L. “Kinesin-1 transport reductions enhance human tau hyperphosphorylation, aggregation and neurodegeneration in animal models of tauopathies.. Human Molecular Genetics, Nov 15;19(22):4399-408, 2010.
  • Falzone T, Stokin G, Lillo C, Rodrigues E, Westerman E, Williams D, Goldstein L. “Axonal Stress Kinase Activation and Tau Misbehavior Induced by Kinesin-1 Transport Defects. Journal of Neuroscience. 29(18):5758-67. May 6, 2009.
  • Stokin G, Lillo C, Falzone T, Brusch R, Rockenstein E, Mount S, Raman R, Davies P, Masliah E, Williams D, Goldstein L. “Axonopathy and transport deficits early in the pathogenesis of Alzheimer’s disease”. Science, 307(5713):1282-8, Feb 25, 2005.