Fecha: Viernes 3 de mayo, 12:00 hs.

Invitado: Prof. Dr. Bertram Müller-Myhsok. Líder del Grupo de Investigación en Estadística Genética. Instituto Max Planck de Psiquiatría, Múnich, Alemania.

Lugar: Sala de Seminarios del IBioBA-CONICET-MPSP. Godoy Cruz 2390, C1425FQD, Buenos Aires, Argentina.

Título: Deciphering subtypes in response to treatment in major depression – a longitudinal approach.

Abstract: In major depression, a very common disorder, the prediction of treatment effects is an area of intense study. Of special interest is the question whether stable, latent treatment subtypes can be detected and predicted. Using mixed model-based clustering on longitudinal Hamilton Disease Rating Scale measures revealed seven distinct treatment response dynamics clusters in a discovery sample (N=834) that were confirmed in two replication samples. Clusters could be predicted from 50 clinical baseline variables, particularly personality items, life events, duration of the episode, and specific psycho¬pathological features, with cluster-derived features performing better than individual-level features, hinting at general validity of the cluster solution.

Eduardo Arzt, Bertram Müller-Myhsok, Damián Refojo.