Information processing in cells and biological tissues

Group Leader

Dr. Luis G. Morelli
See CV

PhD Students

Iván M. Lengyel, Sol M. Fernandez Arancibia, Diego M. Arribas, Fiorella Fabris.

The main questions of our group are: How do cells sense, process information and take decisions? How is information shared among cells and used to orchestrate collective behaviors, for example during embryonic development or in adult tissues?

We are interested in the mechanisms that control information processing at different levels of biological organization. We approach these questions using model systems from developmental biology, embryonic stem cells and neuronal microcircuits, establishing close collaborations with experimental labs.

We employ theoretical approaches to study the dynamics of cellular information processing at the molecular, cellular and tissue levels. We are also interested in how different levels of biological organization are connected, and how they mutually regulate each other. We use and develop methods from dynamical systems theory, stochastic processes and out of equilibrium statistical physics.

Publications related to this Project

  • Petrungaro G, Uriu K, and Morelli LG.
    Mobility-induced persistent chimera states.
    Phys. Rev. E 96, 062210 (2018)
  • Iván M. Lengyel and Luis G. Morelli
    Multiple binding sites for transcriptional repressors can produce regular bursting and enhance noise suppression.
    Phys. Rev. E 95, 042412 (2017)
  • Webb AB, Lengyel IM, Jörg DJ, Valentin G, Jülicher F, Morelli LG, Oates AC
    Persistence, period and precision of autonomous cellular oscillators from the zebrafish segmentation clock.
    eLife 5:e08438 (2016)
  • Soroldoni D, Jörg DJ, Morelli LG, Richmond DL, Schindelin J, Jülicher F, Oates AC
    A Doppler effect in embryonic pattern formation.
    Science 345, 222–225 (2014)
  • Uriu K, Morelli LG
    Collective cell movement promotes synchronization of coupled genetic oscillators.
    Biophys. J. 107, 514–526 (2014)
  • Oates AC, Morelli LG, Ares S
    Patterning embryos with oscillations: the emerging structure, function, and dynamics of the vertebrate segmentation clock.
    Development 139, 625-639 (2012)
  • Morelli LG, Uriu K, Ares S, Oates AC
    Computational Approaches to Developmental Patterning.
    Science 336, 187-191 (2012)
  • Schröter C, Ares S, Morelli LG, Isakova A, Hens K, Soroldoni D, Gajewski M, Jülicher F, Maerkl SJ, Deplancke B, Oates AC
    Topology and dynamics of the zebrafish segmentation clock core circuit.
    PLoS Biol. 10, e1001364 (2012)
  • Herrgen L, Ares S, Morelli LG, Schröter C, Jülicher F, Oates AC
    Intercellular coupling regulates the period of the segmentation clock.
    Current Biology 20, 1244-1253 (2010)
  • Morelli LG, Jülicher F
    Precision of genetic oscillators and clocks.
    Phys. Rev. Lett. 98, 228101 (2007)