Information processing in cells and biological tissues

Group Leader

Dr. Luis G. Morelli
See CV

PhD Students

Fiorella Fabris, Marcos Wappner.

The main questions of our group are: How do cells sense, process information and take decisions? How is information shared among cells and used to orchestrate collective behaviors, for example during embryonic development or in adult tissues?

We are interested in the mechanisms that control information processing at different levels of biological organization. We approach these questions using model systems from developmental biology, embryonic stem cells and neuronal microcircuits, establishing close collaborations with experimental labs.

We employ theoretical approaches to study the dynamics of cellular information processing at the molecular, cellular and tissue levels. We are also interested in how different levels of biological organization are connected, and how they mutually regulate each other. We use and develop methods from dynamical systems theory, stochastic processes and out of equilibrium statistical physics.

Publications related to this Project

  • K Uriu, B-K Liao, AC Oates and LG Morelli
    From local resynchronization to global pattern recovery in the zebrafish segmentation clock
    eLife 10:e61358 (2021)
  • Petrungaro G,  Uriu K, Morelli LG.
    Synchronization dynamics of mobile oscillators in the presence of coupling delays.
    Phys. Rev. E 99:062207 (2019).
  • Lleras-Forero L, Narayanan R, Huitema LF, VanBergen M, Apschner A, Peterson-Maduro J, Logister I, Valentin G, Morelli LG*, Oates AC*, Schulte-Merker S*.
    Segmentation of the zebrafish axial skeleton relies on notochord sheath cells and not on the segmentation clock.
    eLife 7:e33843 (2018).
  • Jörg DJ, Morelli LG,  Jülicher F.
    Chemical event chain model of coupled genetic oscillators.
    Phys. Rev. E 97:032409 (2018).
  • Petrungaro G, Uriu K, Morelli LG.
    Mobility-induced persistent chimera states.
    Phys. Rev E 96:062210 (2017).
  • Lengyel IM, Morelli LG.
    Multiple binding sites for transcriptional repressors can produce regular bursting and enhance noise suppression.
    Phys. Rev. E 95:042412 (2017).
  • Webb AB, Lengyel IM, Jörg DJ, Valentin G, Jülicher F, Morelli LG, Oates AC.
    Persistence, period and precision of autonomous cellular oscillators from the zebrafish segmentation clock.
    eLife 5:e08438 (2016).
  • Uriu K, Morelli LG.
    Collective cell movement promotes synchronization of coupled genetic oscillators.
    Biophys. J. 107: 514–526 (2014).
  • Uriu K, Morelli LG, Oates AC.
    Interplay between intercellular signaling and cell movement in development.
    Seminars in Cell and Developmental Biology 35: 66–72 (2014).
  • Soroldoni D, Jörg DJ, Morelli LG, Richmond DL, Schindelin J, Jülicher F, Oates AC.
    A Doppler effect in embryonic pattern formation.
    Science 345: 222–225 (2014).
  • Jörg D, Morelli LG, Ares S, Jülicher F.
    Synchronization dynamics in the presence of coupling delays and phase shifts.
    Phys. Rev. Lett. 112: 174101 (2014).